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Keep an eye on Intently (one)oxcarbazepine will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to some lower in fentanyl plasma concentrations, not enough efficacy or, probably, growth of a withdrawal syndrome